Btg3 and p53

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August undefined, 2024

WebGal-3 is down-regulated by wt-p53 and this repression is required for p53-induced apoptosis. Since poorly differentiated thyroid carcinomas (PDTCs) and anaplastic thyroid … WebFeb 1, 2000 · Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was induced in response to DNA damage …

BTG3 - Wikipedia

WebAbstract Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, … WebDec 11, 2024 · B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and is a downstream target of p53.Here, we show that senescence triggered … chatham baseball.com

p53 Targets - esbl.nhlbi.nih.gov

WebJul 5, 2012 · The B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG gene family and a downstream target of p53. BTG3 also binds and inhibits … WebOct 17, 2013 · BTG3 is a downstream target of p53 and also binds and inhibits E2F1. It connects functionally those two major growth-regulatory pathways. BTG3 triggers acute cellular senescence via the ERK-JMJD3-p16 signaling axis. However, the expression pattern and functions of BTG3 in HCC remain unknown. In this study, we detected the … Webp53 is a transcription factor that activates many genes involved in essential maintenance of genetic stability. P53 is the most frequently mutated gene in human cancers. One-third of … customised bags australia

The Suppressive Role and Aberrent Promoter Methylation of BTG3 …

The candidate tumor suppressor BTG3 is a transcriptional …

WebBTG3. Protein BTG3 is a protein that in humans is encoded by the BTG3 gene. [5] [6] The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein might play a role in neurogenesis in the central nervous system. WebJan 8, 2015 · BTG3 (B-cell translocation gene 3) is a p53 target that also binds and inhibits E2F1. Although it connects two major growth-regulatory pathways functionally and is … chatham bars inn tennis court feesWebbtg3在g1期表达量最高，g1-s期表现出峰值[16]。 BTG3表达缺失与肺癌的发生有关[17]，也能增强BMP诱导的骨形成[18]。肌肉生长抑制素(Myostatin，MSTN) 基因是TGF-β超家族成员，是骨骼肌生长的负调控因子，为生长发育性状的候选基因。 customised badges

"WebSep 20, 2014 · BTG3 overexpression up- regulated the protein expression of Cyclin E, p16, p27, NF-κB, p38α/β, XIAP, Bcl-2, ATG14 and p53, but down-regulated the mRNA expression of MRP1, BCRP, and mTOR in ... " - Btg3 and p53

Btg3 and p53

Northern analysis of BTG3 RNA before and after DNA damage. ( A ...

WebMar 1, 2000 · B-cell translocation gene 3 (BTG3), also known as ANA, TOB5, TOFA, APRO4, TOB55, and ANA/BTG3, belongs to the BTG gene family and plays its role as a downstream target of p53 [8] [9]. BTG3 has a ... WebJun 1, 2024 · BTG3 (B-cell translocation gene 3), a candidate tumor suppressor gene, is a member of the antiproliferative BTG/Transducer of ErbB2 gene family and is induced by genotoxic stress in a p53- and CHK1-dependent manner (Cheng et al., 2013).

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WebFeb 19, 2024 · PDF BTG4 is the last cloned and poorly studied member of BTG/Tob family. Studies have suggested that BTG4 is critical for the degradation of maternal... Find, read and cite all the research ... WebJan 27, 2016 · p53 deficiency leads to increased growth at metastatic sites. Tumor-bearing mice were monitored for signs of declining health and euthanized when they exhibited …

WebOther articles where TP53 is discussed: tumour suppressor gene: …tumour suppressor genes (such as TP53, which encodes a protein known as p53) have been identified. The mutated form of TP53 has been implicated in … WebAug 9, 2007 · Proper regulation of cell cycle progression is pivotal for maintaining genome stability. In a search for DNA damage-inducible, …

WebDec 4, 2024 · BTG3 is a direct downstream target of miR-106b-5p. BTG3 overexpression inhibited tumor growth of SW620 cells by suppressing proliferation and inducing … WebCDKN1A is also known as p21, which is a cell cycle inhibitor and downstream effector of p53, while BTG3 is a member of the antiproliferative BTG gene family and has been identified as a direct ...

Webp53. Target Genes. Recent genome-wide analyses and meta-analyses of genome-wide datasets of p53 DNA-binding and gene regulation show that p53 is a direct activator of a limited number of genes compared to the number of putative response-elements identified genome-wide. They also provide evidence that p53 is not a direct repressor of genes .

WebDec 8, 2024 · Enables p53 binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of protein catabolic process and protein localization to nucleus. Located in nucleus. Is expressed in bladder; heart; musculature; spleen; and thymus. Orthologous to human BANP (BTG3 associated … customised bagsWebB-cell translocation gene 3 (BTG3), recognized as a member of an antiproliferative B-cell translocation gene/ Transducer of ErbB2 (BTG/Tob) gene family, is a downstream target of p53 and is induced upon … customised baby t shirtWebp53 regulated genes curated by M. Fisher (Fischer M. Census and evaluation of p53 target genes. Oncogene. 2024; 36: 3943-3956. PMID: 28288132 ). All genes have been converted to mouse. Database was created by Angela Mak and Mark Knepper in the Epithelial Systems Biology Laboratory (Mark Knepper, Chief) at the National Heart, Lung and Blood ... customised badges australiaWebDownload scientific diagram BTG3 protein is induced by DNA damage in a p53-dependent manner. ( A ) BTG3 in LNCaP cells is induced by various DNA damage agents. Cells were treated with 8 Gy of X ... chatham bars inn wedding with bruno marsWebSep 16, 2024 · B cell transposition gene 3 (BTG3) is reported to be a tumor suppressor and suppresses proliferation and cell cycle progression. This study aims to analyze the clinicopathological and prognostic significances, and signal pathways of BTG3 mRNA expression in human beings through bioinformatics analysis. We analyzed BTG3 … customised badges singaporeWebRecently, we have shown that BTG2/TIS21 gene expression was induced in response to DNA damage through a p53‐dependent pathway. This gene belongs to a newly identified family of structurally related genes whose other known human members are BTG1, BTG3, and Tob. ... BTG3, and Tob. To define the respective involvement of these four related … customised badges cheapWebBTG3 is a p53 target that binds to the transcription factor E2F1, inhibiting its expression. BTG3 suppresses AKT activity, which is frequently deregulated in many cancers [90] . customised baby gifts