Cisplatin nephropathy

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August undefined, 2024

WebSide effect and toxicity management Prophylaxis and treatment Prevention and management of cisplatin nephrotoxicity ID: 184 v.3 Endorsed This document is an … WebAug 14, 2024 · Nephrotoxicity associated with cisplatin administration is common and unwanted adverse effect which has significantly restricted its clinical use [ 1 ]. Both acute and chronic nephrotoxicities associated with cisplatin tend to occur more frequently at higher doses or especially after repeated administration [ 2 ].

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WebIn order to confirm the additional adverse effects of KU55933 on cisplatin-induced DNA damage and to elucidate the For all groups, data are means ± SEM, *p < 0.05 vs control, # p < 0.05 vs ... WebApr 12, 2024 · Cisplatin is a highly effective anti-cancer agent used in the treatment of solid organ tumors, such as head and neck, lung, breast, testis, and ovarian cancers 1, 2. Although cisplatin has... deutsche boerse ag annual report

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WebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, Webwww.karger.com WebFeb 2, 2024 · 5.1 Cisplatin-Induced Nephrotoxicity. Cisplatin, ... Let us pay attention to whether, the body affected by nephropathy also causes further nephrotoxicity by breaking the balanced relationship between the two pathways, in addition to nephrotoxicity caused by the crosstalk of Nrf2 and NF-κB. When exploring whether diabetes aggravates I/R … church easter dresses

Molecular mechanisms of cisplatin-induced …

WebKidney disease, or renal disease, technically referred to as nephropathy, is damage to or disease of a kidney. Nephritis is an inflammatory kidney disease and has several types according to the location of the inflammation. Inflammation can be diagnosed by blood tests. Nephrosis is non-inflammatory kidney disease. WebCisplatin is an important chemotherapeutic drug for the treatment of solid tumors but often causes nephropathy as part of the off-target toxicity. Iron accumulation and related damage were implicated in cisplatin-induced kidney injury. deutsche boerse ag share priceWebJan 11, 2024 · Malignant obstructive nephropathy in MIBC does not usually resolve with complete transurethral resection of the tumour alone or with cisplatin-based neoadjuvant chemotherapy 82,83 and might ... church easter egg hunt 2023 near me

"WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of cancer. Cisplatin has been associated with a low rate of serum enzyme elevations and with rare cases of clinically apparent, acute liver injury. " - Cisplatin nephropathy

Cisplatin nephropathy

WebNational Center for Biotechnology Information WebDec 13, 2024 · Cisplatin and carboplatin are platinum-based antineoplastic agents. Approximately 30% of patients receiving cisplatin have acute kidney injury (AKI), and it is not unusual for subsequent treatment to be limited [].On the other hand, carboplatin, which was developed as a derivative of cisplatin in the same platinum formulation, is …

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WebCisplatin was the first platinum compound to be introduced as a chemotherapeutic agent with antineoplastic activity against a wide variety of solid tumors. Renal impairment with … WebJul 22, 2024 · Cisplatin nephropathy is a representative chemotherapeutic agent-related AKI. The molecular mechanisms underlying cisplatin-induced AKI have long been the subjects of research, and a number of studies have demonstrated the involvement of mitochondrial dysfunction, oxidative stress, inflammation, and apoptosis in renal tubular …

WebSep 15, 2008 · In thrombotic microangiopathy, organ damage is caused by platelet thrombi in the microcirculation, as in thrombotic thrombocytopenic purpura. 30 Mechanisms of renal injury secondary to drug-induced... WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic …

WebJan 1, 1996 · CsA nephropathy was introduced as a PRD in the ERA-EDTA Registry in 1985 and, despite its rarity, is of particular interest as a new iatrogenic entity resulting from CsA administration, mainly in solid organ transplantation. In 1985, two new patients commenced RRT in Europe, and the number increased to 59 in 1991–93. WebNational Center for Biotechnology Information

Webcisplatin-induced nephrotoxicity has not been well studied. Intracellular Events that Damage Renal Cells The in vivo mechanisms of cisplatin nephrotoxic-ity are … church easter door hangersWebSep 15, 2008 · Cisplatin (Platinol) Chronic interstitial nephritis, tubular cell toxicity: Interferon-alfa (Intron A) Glomerulonephritis: Methotrexate: Crystal nephropathy: … deutsche boerse group share priceWebA large and growing number of studies have shown that patients with chronic kidney disease are less likely to undergo coronary angiography and revascularization than patients who do not have... deutsche boerse ag investor relationsWebNov 11, 2024 · Cisplatin (CDDP), a platinum drug, has been universally utilized to treat bladder cancer, ovarian cancer and other solid tumors ( Dasari and Tchounwou, 2014 ). However, the dominant factor restricting the clinical use of cisplatin is its nephrotoxicity ( Zhu et al., 2015 ). church easter decorations ideasWebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … church easter flyerWebNephropathy can be associated with some therapies used to treat cancer. The most common form of kidney disease in cancer patients is Acute Kidney Injury (AKI) which can … church easter egg hunt flyer templateWebJul 22, 2024 · It is important to note that for many malignancies, cisplatin is used in combination with other drugs that may also be nephrotoxic. Cellular toxicity — Cisplatin (cis-diamminedichloroplatinum II [CDDP]), a platinum compound that is predominantly … church easter decorations pics