WebMar 2, 2009 · Cytoplasmic polyadenylation is required for growth cone collapse. (A) Typical examples of collapsed and non-collapsed growth cones. (B) Cordycepin (200 μM; 3'deoxyadenosine; Cordy), but not adenosine (Adeno), blocks Sema3A-induced growth cone collapse. (C) Cordycepin does not affect lysophosphatidic acid (LPA)-induced … WebThe cytoplasmic polyadenylation element binding proteins are important for translation regulation, and CPEB3 is specifically responsible for binding a novel translation-regulating signal that consists of a stem-loop with a U-rich bulge. 99,100 Expression of CPEB3 occurs in a wide range of tissues and is increased in mouse hippocampus following …
Cytoplasmic Polyadenylation Element Binding Protein
There is polyadenylation in the cytosol of some animal cell types, namely in the germ line, during early embryogenesis and in post-synaptic sites of nerve cells. This lengthens the poly(A) tail of an mRNA with a shortened poly(A) tail, so that the mRNA will be translated. These shortened poly(A) tails are often … See more Polyadenylation is the addition of a poly(A) tail to an RNA transcript, typically a messenger RNA (mRNA). The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that … See more Function In nuclear polyadenylation, a poly(A) tail is added to an RNA at the end of transcription. On mRNAs, the poly(A) tail protects the mRNA molecule from enzymatic degradation in the cytoplasm and aids in … See more For many non-coding RNAs, including tRNA, rRNA, snRNA, and snoRNA, polyadenylation is a way of marking the RNA for degradation, at least in yeast. This polyadenylation is … See more Although polyadenylation is seen in almost all organisms, it is not universal. However, the wide distribution of this modification and the fact that it is present in organisms from all three domains of life implies that the last universal common ancestor of all living organisms, it … See more RNAs are a type of large biological molecules, whose individual building blocks are called nucleotides. The name poly(A) tail (for … See more Many protein-coding genes have more than one polyadenylation site, so a gene can code for several mRNAs that differ in their 3′ end. The 3’ region of a transcript contains many polyadenylation signals (PAS). When more proximal (closer towards 5’ end) … See more In many bacteria, both mRNAs and non-coding RNAs can be polyadenylated. This poly(A) tail promotes degradation by the degradosome, which contains two RNA-degrading … See more WebAbstract. Poly (A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and … bird watching tehcniques around water
Cytoplasmic polyadenylation-mediated translational control of …
WebHere, we report that Cpeb1b-mediated cytoplasmic polyadenylation is important for HSPC specification by translational control of Hedgehog (Hh) signaling during zebrafish early … WebNov 24, 2015 · The cytoplasmic polyadenylation (CP) element, Pumilio binding element, and hexanucleotide polyadenylation signal are among the best understood motifs involved in CP, and translational regulation of stored transcripts as their binding partners have been relatively well-characterized. Knowledge of CP in mammalian oocytes is discussed as … bird watching tips for kids