Immunity-related gtpase family m protein 1
Witryna22 sty 2024 · This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to …
Immunity-related gtpase family m protein 1
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Witryna6 maj 2011 · Here, we examined a complete mouse 65-kilodalton (kD) guanylate-binding protein (Gbp) gene family as part of a 43-member IFN-γ–inducible guanosine triphosphatase (GTPase) superfamily in mouse and human genomes. Family-wide loss-of-function analysis found that at least four Gbps—Gbp1, Gbp6, Gbp7, and … Witryna10 kwi 2024 · RhoA is a small GTPase in the Rho family and is involved in several cellular processes, including cell proliferation and differentiation. ... Our results showed that DSS treatment leads to decreased levels of the tight junction proteins, ZO-1 and occludin, in Caco-2 cells and increased levels of RhoA, ROCK1, and ROCK2; …
WitrynaThe prototypical DOCK protein, DOCK180, is an evolutionarily conserved Rac regulator and is indispensable during processes such as cell migration and myoblast fusion. The biological activity of DOCK180 is tightly linked to its binding partner ELMO. We previously reported that autoinhibited ELMO proteins regulate signaling from this pathway. WitrynaImmunity-related GTPase family M protein (IRGM) participates in immune response to pathogen and tumorigenesis. Proliferation and autophagy are two crucial functions contributing to aggressive growth. Therefore, our aims were to probe whether IRGM regulates glioma proliferation and autophagy. In this study, we found that 47 glioma …
Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is encoded by the IRGM gene. IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating … Zobacz więcej Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis. Zobacz więcej • Laukens D, Georges M, Libioulle C, Sandor C, Mni M, Vander Cruyssen B, et al. (November 2010). "Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis" Zobacz więcej WitrynaThe small GTPase RAC1 is a member of the Rho family of small GTPases and participates in signaling pathways that regulate cytoskeletal organization, cell proliferation and survival, and gene transcription ... (protein identifier P63000-1), and the RAC1-202 transcript encodes a 211 amino acid protein, called RAC1B (protein identifier …
Witryna1 kwi 2024 · Alemtuzumab, a CD52-depleting monoclonal antibody, is currently used in the treatment of hematological tumors. FNBP1 is an actin cytoskeleton-associated protein associated with tumor cell migration and invasion. It has been demonstrated that the GTPase family member GBP1 is essential for tumor development [29].
Witryna6 kwi 2024 · Ran binding protein 1 (RanBP1), which is expressed between eukaryotes and vertebrates, but not in some invertebrate species such as flies and worms, is a Ran-GTP-binding protein [].It is a co-activator of the Ran-GTPase activating protein, RanGAP1 [].RanBP1 plays a role in Ran-dependent nucleocytoplasmic transport … chip fallbackWitrynaImmunity-Related GTPase Family M Protein Known as: LPS-Stimulated RAW 264.7 Macrophage Protein 47 Homolog , EC 3.6.5.- , Interferon-Inducible Protein 1 Expand Immunity-related GTPase family M protein (181 aa, ~20 kDa) is encoded by the human IRGM gene. chip failWitryna2 dni temu · Orthologous to human IRGM (immunity related GTPase M). [provided by Alliance of Genome Resources, Apr 2024] Other designations. immunity-related GTPase family M protein 1, LPS-stimulated RAW 264.7 macrophage protein 47, immunity related GTPase m1, interferon-gamma-inducible GTPase Ifggd3 protein, … chip fallback transactionWitryna2 wrz 2011 · The immunity-related GTPases (IRGs) are a family of proteins induced by interferon-γ that play a crucial role in innate resistance to intracellular pathogens. The M subfamily of IRG proteins (IRGM) plays a profound role in this context, in part because of the ability of its members to regulate the localization and expression of … chip fallback non atmWitrynaGuanylate-binding proteins (GBP) are a family of dynamin-related large GTPases which are expressed in response to interferons and other pro-inflammatory cytokines. GBPs mediate a broad spectrum of innate immune functions against intracellular pathogens ranging from viruses to bacteria and protozoa. … grant memorial cemeteryWitryna22 sty 2024 · NM_001355757.1 → NP_001342686.1 immunity-related GTPase family M protein 1 isoform 2. Status: VALIDATED. Description Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N … grant memorial building bethel ohioWitrynaGIMAP has been identified as a GTPase of immune-associated proteins that play a crucial role in immune mechanisms, especially T cell production, development and stable immune processes. 3 GIMAP mRNAs are majorly expressed in the spleen and lymphoid, ... GIMAP family is also closely related to tumour immunity. grant memorial church hymn sing